FUT10
Developmental stage
Expressed in fetal tissues including skin, small intestine, liver, kidney, lung, muscle, heart and brain.
Isoform 4
Expressed in 50 day old embryo.
Isoform 5
Expressed in 50 day old embryo.
Function
Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation (PubMed:19088067). Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity).
Isoform 1
Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit.
Isoform 4
Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit.
Isoform 5
Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit.
Pathway
Protein modification; protein glycosylation.
Sequence Similarities
Belongs to the glycosyltransferase 10 family.
Tissue Specificity
Expressed in lung, digestive tract, gall bladder, placenta, kidney, uterus and brain. Not detected in spleen, heart, muscle, liver and pancreas.
Cellular localization
- Isoform 1
- Endoplasmic reticulum membrane
- Single-pass type II membrane protein
- Golgi apparatus membrane
- Single-pass type II membrane protein
- Isoform 4
- Golgi apparatus
- Lysosome
- Isoform 5
- Endoplasmic reticulum membrane
- Single-pass type II membrane protein
- Golgi apparatus membrane
- Single-pass type II membrane protein
Alternative names
Fucosyltransferase X, Galactoside 3-L-fucosyltransferase 10, Fuc-TX, FucT-X, Fucosyltransferase 10, FUT10