FUT4

Function

Isoform Short

Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins (PubMed:1702034, PubMed:1716630, PubMed:29593094). Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins (PubMed:1716630, PubMed:29593094). Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (PubMed:11278338, PubMed:1716630).

Isoform Long

Does not generate Lewis X antigens.

Pathway

Isoform Short

Protein modification; protein glycosylation.

Sequence Similarities

Belongs to the glycosyltransferase 10 family.

Tissue Specificity

Isoform Short

Expressed at low levels in bone marrow-derived mesenchymal stem cells.

Expressed in cord blood immature promyelocytes and in peripheral blood myeloid and lymphoid cell populations.

Cellular localization

• Golgi apparatus
• Golgi stack membrane
• Single-pass type II membrane protein
• Membrane-bound form in trans cisternae of Golgi.

Alternative names

ELFT, FCT3A, FUT4, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, ELAM-1 ligand fucosyltransferase, Fucosyltransferase 4, Fucosyltransferase IV, Galactoside 3-L-fucosyltransferase, Fuc-TIV, FucT-IV

Database links

swissprot:P22083 omim:104230 swissprot:P51993 swissprot:Q11128 swissprot:Q11130 swissprot:Q9Y231 entrezGene:2526 entrezGene:2527 entrezGene:2528 entrezGene:2529 entrezGene:10690