FUZ
Function
Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia. Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity).
Sequence Similarities
Belongs to the fuzzy family.
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Cytoskeleton
- Cilium basal body
Alternative names
FY, FUZ, Protein fuzzy homolog