FXYD5

Function

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). May increase NKA activity by increasing the apparent affinity for Na(+) (PubMed:18263667). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (PubMed:11756660).

Post-translational modifications

Glycosylated.

Sequence Similarities

Belongs to the FXYD family.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Basolateral cell membrane
• Single-pass type I membrane protein
• In kidneys localizes to the basolateral membrane of the connecting tubule.

Alternative names

DYSAD, IWU1, HSPC113, UNQ2561/PRO6241, FXYD5, FXYD domain-containing ion transport regulator 5, Dysadherin

Database links

swissprot:Q96DB9 entrezGene:53827 omim:606669 genbank:NP_054883