FXYD6
Function
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Reduces the apparent affinity for intracellular Na(+) with no change in the apparent affinity for extracellular K(+) (PubMed:33231612). In addition to modulating NKA kinetics, may also function as a regulator of NKA localization to the plasma membrane (By similarity).
Sequence Similarities
Belongs to the FXYD family.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
UNQ521/PRO1056, FXYD6, FXYD domain-containing ion transport regulator 6, Phosphohippolin