G

Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.

Glycosylated and palmitoylated by host. Glycosylation is crucial for glycoprotein export at the cell surface.

Belongs to the lyssavirus glycoprotein family.

• Virion membrane
• Single-pass type I membrane protein

Glycoprotein, G

• swissprot:P03524

Proteins

Immunology & Infectious Disease

58658Da