G
Function
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
Post-translational modifications
Glycosylated and palmitoylated by host. Glycosylation is crucial for glycoprotein export at the cell surface.
Sequence Similarities
Belongs to the lyssavirus glycoprotein family.
Cellular localization
- Virion membrane
- Single-pass type I membrane protein
Alternative names
Glycoprotein, G