GAD2

Function

Catalyzes the production of GABA.

Post-translational modifications

Phosphorylated; which does not affect kinetic parameters or subcellular location.

Palmitoylated; which is required for presynaptic clustering.

Sequence Similarities

Belongs to the group II decarboxylase family.

Cellular localization

• Cytoplasm
• Cytosol
• Cytoplasmic vesicle
• Presynaptic cell membrane
• Lipid-anchor
• Golgi apparatus membrane
• Peripheral membrane protein
• Cytoplasmic side
• Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.

Alternative names

GAD65, GAD2, Glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, Glutamate decarboxylase 65 kDa isoform, GAD-65

Database links

swissprot:Q05329 omim:138275 omim:605363 swissprot:Q99259 entrezGene:2571 entrezGene:2572