Growth arrest and DNA damage-inducible proteins-interacting protein 1

Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.

Belongs to the mitochondrion-specific ribosomal protein mL64 family.

Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.

• Mitochondrion
• Nucleus
• Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275).

MRPL59, PLINP1, PRG6, GADD45GIP1, Large ribosomal subunit protein mL64, CKII beta-associating protein, CR6-interacting factor 1, Growth arrest and DNA damage-inducible proteins-interacting protein 1, Papillomavirus L2-interacting nuclear protein 1, p53-responsive gene 6 protein, MRP-L59, CRIF1, PLINP, PLINP-1

• entrezGene:90480
• omim:605162
• swissprot:Q8TAE8

Proteins

Metabolism

25384Da