GAP43
GeneName
GAP43
Summary
GAP43, also known as growth associated protein 43 or protein F1, is a 25 kDa protein predominantly expressed in the nervous system, particularly in neurons. It is localised to various cellular compartments including the cytoplasm, dendrites, growth cones, and synapses, where it plays a vital role in axon growth and regeneration. GAP43 is involved in the regulation of filopodium assembly and postsynaptic specialisation, and its interactions with phospholipids and calmodulin suggest a role in signal transduction pathways that govern neuronal development and plasticity.
Importance
GAP43 is relevant to: - Neuronal development and plasticity, influencing axon regeneration and synaptic formation - Neurodegenerative diseases, as its expression is associated with neuronal repair mechanisms - Understanding the mechanisms of learning and memory, given its role in synaptic function - Potential therapeutic targets in enhancing nerve regeneration following injury or in neurodegenerative conditions.
Top Products
For researchers investigating GAP43, we highly recommend the top-selling recombinant antibody, Anti-GAP43 antibody [EP890Y] (ab75810). This well-cited antibody has garnered 122 citations, reflecting its strong reputation in the field. It has been validated for a variety of applications, including Western blotting (WB), immunohistochemistry (IHC), immunocytochemistry (ICC), flow cytometry (FC), and immunoprecipitation (IP). The versatility and reliability of this antibody make it an excellent choice for those studying GAP43 in various experimental contexts. The Anti-GAP43 antibody ELISA Kit (ab232772), supported by 3 citations, is an excellent option for researchers looking to accurately measure GAP43 levels in their samples.
Abcam Product Citation Summary
The data indicates that GAP43 is being studied in various contexts related to nerve regeneration, axonal growth, and cell differentiation. The use of Abcam antibody ab75810 in both human and mouse models highlights its relevance in understanding neurobiological processes and potential therapeutic approaches for nerve injuries.
Abcam Product Citation Table
Function
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Post-translational modifications
Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction (PubMed:14978216). Deacylated by LYPLA2 (PubMed:21152083).
Sequence Similarities
Belongs to the neuromodulin family.
Cellular localization
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cell projection
- Growth cone membrane
- Peripheral membrane protein
- Cytoplasmic side
- Synapse
- Cell projection
- Filopodium membrane
- Peripheral membrane protein
- Perikaryon
- Cell projection
- Dendrite
- Cell projection
- Axon
- Cytoplasm
- Cytoplasmic surface of growth cone and synaptic plasma membranes.
Alternative names
Neuromodulin, Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46, GAP43
Database links
swissprot:P17677 omim:162060 genbank:NP_002036 entrezGene:2596