GAP43

This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).

Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction (PubMed:14978216). Deacylated by LYPLA2 (PubMed:21152083).

Belongs to the neuromodulin family.

• Cell membrane
• Peripheral membrane protein
• Cytoplasmic side
• Cell projection
• Growth cone membrane
• Peripheral membrane protein
• Cytoplasmic side
• Synapse
• Cell projection
• Filopodium membrane
• Peripheral membrane protein
• Perikaryon
• Cell projection
• Dendrite
• Cell projection
• Axon
• Cytoplasm
• Cytoplasmic surface of growth cone and synaptic plasma membranes.

Neuromodulin, Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46, GAP43

• entrezGene:2596
• genbank:NP_002036
• omim:162060
• swissprot:P17677

Proteins

Neuroscience

24803Da