Gas6

Function

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

Post-translational modifications

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

Cellular localization

• Secreted

Alternative names

Growth arrest-specific protein 6, GAS-6, AXL receptor tyrosine kinase ligand, Gas6

Database links

swissprot:Q61592 entrezGene:14456

Other research areas

• Neuroscience