Gast
Function
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Post-translational modifications
Sulfation on Tyr-87 enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins and between tissues (By similarity).
Sequence Similarities
Belongs to the gastrin/cholecystokinin family.
Cellular localization
- Secreted
Alternative names
Gas, Gast, Gastrin