GATA3 phospho S308
Domain
Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation.
The YxKxHxxxRP motif is critical for DNA-binding and function.
Function
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
Involvement in disease
Hypoparathyroidism, sensorineural deafness, and renal disease
HDR
A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia.
None
The disease is caused by variants affecting the gene represented in this entry.
Tissue Specificity
T-cells and endothelial cells.
Cellular localization
- Nucleus
Alternative names
Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, GATA3
Database links
Other research areas
- Epigenetics
- Immuno-oncology
- Oncology