Gata3 phospho S308

Domain

Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation (By similarity).

The YxKxHxxxRP motif is critical for DNA-binding and function.

Function

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (PubMed:31175139). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.

Tissue Specificity

T-cell specific.

Cellular localization

• Nucleus

Alternative names

Gata-3, Gata3, Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3

Database links

swissprot:P23772 entrezGene:14462

Other research areas

• Epigenetics
• Immuno-oncology
• Oncology