GATA3

Domain

Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation.

The YxKxHxxxRP motif is critical for DNA-binding and function.

Function

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.

Involvement in disease

Hypoparathyroidism, sensorineural deafness, and renal disease

HDR

A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia.

None

The disease is caused by variants affecting the gene represented in this entry.

Tissue specificity

T-cells and endothelial cells.

Cellular localization

• Nucleus

Alternative names

• Trans-acting T-cell-specific transcription factor GATA-3
• GATA-binding factor 3
• GATA3

Database links

• entrezGene:2625
• omim:131320
• swissprot:P23771

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Epigenetics
• Immuno-oncology
• Oncology

Molecular weight

47916Da