GATA3

Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation.

The YxKxHxxxRP motif is critical for DNA-binding and function.

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.

Hypoparathyroidism, sensorineural deafness, and renal disease

HDR

A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia.

None

The disease is caused by variants affecting the gene represented in this entry.

T-cells and endothelial cells.

• Nucleus

Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, GATA3

• entrezGene:2625
• omim:131320
• swissprot:P23771

Proteins

Immunology & Infectious Disease

• Epigenetics
• Immuno-oncology
• Oncology

47916Da