GATA3
GeneName
GATA3
Summary
GATA3, also known as GATA-3 or transcription factor GATA-3, is a 48kDa zinc finger transcription factor that plays a crucial role in various developmental processes and cell fate decisions. It is predominantly expressed in the thymus, where it is essential for T cell development, particularly in the differentiation of T-helper 2 (Th2) cells. GATA3 binds to specific DNA sequences in the regulatory regions of target genes, influencing processes such as immune response, morphogenesis, and organ development. It is involved in chromatin remodelling and can act as both an activator and repressor of transcription, depending on the context.
Importance
GATA3 is relevant to: - T cell differentiation and the immune response, particularly in the context of allergic reactions and asthma due to its role in Th2 cell development - Developmental biology, as it is crucial for the morphogenesis of various organs including the heart, kidneys, and inner ear - Cancer research, where it may function as a tumour suppressor or oncogene depending on the cancer type, particularly in breast cancer - Understanding congenital disorders, given its involvement in embryonic organ development and cell fate commitment.
Top Products
For researchers investigating GATA3, we highly recommend the top-selling recombinant antibody, Anti-GATA3 antibody [EPR16651] - ChIP Grade (ab199428). This antibody has been validated in knockout models, ensuring reliable performance across a variety of applications, including Western blotting (WB), immunohistochemistry (IHC), flow cytometry (FC), immunocytochemistry (ICC), and chromatin immunoprecipitation (ChIP). With 92 citations, it is well-regarded in the research community, making it an excellent choice for those seeking robust and consistent results in their studies of GATA3. The Anti-GATA2 + GATA3 antibody ELISA Kit (ab272237) is a reliable option for researchers looking to study GATA3 in their experiments.
Abcam Product Citation Summary
The data indicates that GATA3 is frequently studied in the context of neuroblastoma, particularly in human cell lines and tumor tissues. Additionally, GATA3 is also investigated in mouse models, specifically in mammary glands and tumors, highlighting its role in cell proliferation and differentiation. The presence of GATA3 in human bone marrow specimens suggests its involvement in T helper cell subsets, while its detection in ChIP studies points to its relevance in DNA methylation changes.
Abcam Product Citation Table
Domain
Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation.
The YxKxHxxxRP motif is critical for DNA-binding and function.
Function
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
Involvement in disease
Hypoparathyroidism, sensorineural deafness, and renal disease
HDR
A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia.
None
The disease is caused by variants affecting the gene represented in this entry.
Tissue Specificity
T-cells and endothelial cells.
Cellular localization
- Nucleus
Alternative names
Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, GATA3
Database links
swissprot:P23771 omim:131320 entrezGene:2625
Other research areas
- Epigenetics
- Immuno-oncology
- Oncology