GB

Envelope glycoprotein that forms spikes at the surface of virion envelope and binds to the host cell entry receptors MYH9/NMMHC-IIA and MYH10/NMMHC-IIB, promoting the virus entry into host cells. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell: following initial binding to its host cell entry receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).

The cytoplasmic tail is phosphorylated by the viral kinase US3. Phosphorylation may be linked to a down-regulation of gB expression on cell surface (By similarity).

ubiquitinated.

Belongs to the herpesviridae glycoprotein B family.

• Virion membrane
• Single-pass type I membrane protein
• Host cell membrane
• Single-pass type I membrane protein
• Host endosome membrane
• Single-pass type I membrane protein
• Host Golgi apparatus membrane
• Single-pass type I membrane protein
• During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).

UL27, gB, Envelope glycoprotein B

• swissprot:P10211

Proteins

Immunology & Infectious Disease

100292Da