GBGT1

The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity).

Has lost the ability to synthesize Forssman glycolipid antigen (FORS1/FG) (PubMed:10506200). Might have acquired an alternative function in glycosphingolipid metabolism, but it remains to be established. It appears to have drifted more slowly than confirmed pseudogenes in the glycosyltransferase 6 family, suggesting that it has remained under evolutionary pressure.

Protein modification; protein glycosylation.

Belongs to the glycosyltransferase 6 family.

Widely expressed. Expressed at higher level in placenta, ovary and peripheral blood leukocyte, whereas it is weakly expressed in liver, thymus, and testis (PubMed:10506200). Expressed in bone marrow erythroid cells (PubMed:23255552).

• Golgi apparatus membrane
• Single-pass type II membrane protein

UNQ2513/PRO6002, GBGT1, Forssman glycolipid synthase-like protein

• entrezGene:26301
• omim:606074
• swissprot:Q8N5D6

Proteins

40127Da