Gbp3
Function
Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:24715728, PubMed:24739961). Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product (PubMed:9659399). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24715728, PubMed:24739961). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24715728, PubMed:24739961). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24715728, PubMed:24739961). May play a role in erythroid differentiation (PubMed:9659399).
Sequence Similarities
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
Tissue Specificity
Brain, lung, heart, spleen, kidney, liver and intestine.
Cellular localization
- Cytoplasm
- Cytoplasm
- Perinuclear region
- Golgi apparatus membrane
- Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus.
Alternative names
Guanylate-binding protein 3, GTP-binding protein 3, Guanine nucleotide-binding protein 3, GBP-3, Gbp3