gC
Function
Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate. Also plays several roles in host immune evasion by inhibiting the host complement cascade activation, and by providing a shield against neutralizing antibodies that interfere with gB-gD, gB-gH/gL or gD-gH/gL interactions (By similarity).
Sequence Similarities
Belongs to the herpesviridae glycoprotein C family.
Cellular localization
- Virion membrane
- Single-pass membrane protein
Alternative names
UL44, gC, Envelope glycoprotein C