GCC2
Domain
Extended rod-like protein with coiled-coil domains.
Function
Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Golgi apparatus
- trans-Golgi network membrane
- Peripheral membrane protein
Alternative names
KIAA0336, RANBP2L4, GCC2, GRIP and coiled-coil domain-containing protein 2, 185 kDa Golgi coiled-coil protein, CLL-associated antigen KW-11, CTCL tumor antigen se1-1, Ran-binding protein 2-like 4, Renal carcinoma antigen NY-REN-53, GCC185, RanBP2L4