Gch1
Function
May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence.
Pathway
Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
Post-translational modifications
Phosphorylated.
Sequence Similarities
Belongs to the GTP cyclohydrolase I family.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
Gch, Gch1, GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I