GCHFR
Function
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Sequence Similarities
Belongs to the GFRP family.
Tissue Specificity
In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
Cellular localization
- Nucleus
- Nucleus membrane
- Cytoplasm
- Cytosol
Alternative names
GFRP, GCHFR, GTP cyclohydrolase 1 feedback regulatory protein, GTP cyclohydrolase I feedback regulatory protein, p35