GCNT3
Function
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.
Pathway
Protein modification; protein glycosylation.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the glycosyltransferase 14 family.
Tissue Specificity
Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced.
Cellular localization
- Golgi apparatus membrane
- Single-pass type II membrane protein
Alternative names
C2GnT-mucin type, C2GnT-M, hC2GnT-M, C2/4GnT, GCNT3