gD
Function
Envelope glycoprotein that binds to the host cell entry receptors NECTIN1, TNFRSF14/HVEM and 3-O-sulfated heparan sulfate, promoting the virus entry into host cells (PubMed:22146396). May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).
Sequence Similarities
Belongs to the herpesviridae glycoprotein D family.
Cellular localization
- Virion membrane
- Single-pass type I membrane protein
- Host Golgi apparatus
- During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs.
Alternative names
US6, gD, Envelope glycoprotein D