GDF10

Function

Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.

Sequence Similarities

Belongs to the TGF-beta family.

Tissue Specificity

Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.

Cellular localization

• Secreted

Alternative names

BMP3B, GDF10, Growth/differentiation factor 10, GDF-10, Bone morphogenetic protein 3B, Bone-inducing protein, BMP-3B, BIP

Database links

swissprot:P55107 entrezGene:2662 genbank:NM_004962 omim:601361