GDI2
Function
GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027).
Sequence Similarities
Belongs to the Rab GDI family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Membrane
- Peripheral membrane protein
Alternative names
RABGDIB, GDI2, Rab GDP dissociation inhibitor beta, Rab GDI beta, Guanosine diphosphate dissociation inhibitor 2, GDI-2