GDNF family receptor alpha-4

Function

Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons (PubMed:11116144). Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor (PubMed:11116144). May be important in C-cell development and, in the postnatal development of the adrenal medulla (PubMed:11116144).

Sequence Similarities

Belongs to the GDNFR family.

Tissue Specificity

Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.

Cellular localization

• Isoform GFRalpha4a
• Cell membrane
• Lipid-anchor
• GPI-anchor
• Isoform GFRalpha4b
• Cell membrane
• Lipid-anchor
• GPI-anchor
• Isoform GFRalpha4c
• Secreted

Alternative names

GDNF family receptor alpha-4, GDNF receptor alpha-4, GDNFR-alpha-4, GFR-alpha-4, Persephin receptor, GFRA4

Database links

swissprot:Q9GZZ7 entrezGene:64096