GDPD3
Function
Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.
Sequence Similarities
Belongs to the glycerophosphoryl diester phosphodiesterase family.
Tissue Specificity
Widely expressed, with high level in kidney and ovary.
Cellular localization
- Membrane
- Multi-pass membrane protein
- Cytoplasm
- Perinuclear region
- Endoplasmic reticulum
- Partially co-localized with CANX.
Alternative names
GDE7, GDPD3, Lysophospholipase D GDPD3, Glycerophosphodiester phosphodiesterase 7, Glycerophosphodiester phosphodiesterase domain-containing protein 3