Gfap

Function

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

Post-translational modifications

Phosphorylated by PKN1.

Sequence Similarities

Belongs to the intermediate filament family.

Tissue Specificity

Brain; isoform 2 expressed at 20-fold lower level than isoform 1.

Cellular localization

• Cytoplasm
• Associated with intermediate filaments.

Alternative names

Glial fibrillary acidic protein, GFAP, Gfap

Database links

swissprot:P03995 entrezGene:14580

Other research areas

• Cardiovascular