GFRA2
Function
Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons (PubMed:10829012, PubMed:29414779, PubMed:31535977, PubMed:9182803). NRTN-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977). Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (PubMed:9182803).
Isoform 2
Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
Sequence Similarities
Belongs to the GDNFR family.
Tissue Specificity
Isoform 1
found in both brain and placenta.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
GDNFRB, RETL2, TRNR2, GFRA2, GDNF family receptor alpha-2, GDNF receptor alpha-2, GDNFR-alpha-2, GFR-alpha-2, GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, GDNFR-beta, NRTNR-alpha, NTNR-alpha