GGA1

The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (DXXLL motif).

The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis.

The unstructured hinge region contains clathrin-binding but no autoinhibitory (DXXLL) motifs.

The GAE domain binds accessory proteins regulating GGAs function.

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712, PubMed:15886016).

Phosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal DXXLL motif to bind the VHS domain and to inhibit the recognition of cargo signals.

Ubiquitinated.

Belongs to the GGA protein family.

Ubiquitously expressed.

• Golgi apparatus
• trans-Golgi network membrane
• Peripheral membrane protein
• Endosome membrane
• Peripheral membrane protein
• Early endosome membrane
• Peripheral membrane protein

ADP-ribosylation factor-binding protein GGA1, Gamma-adaptin-related protein 1, GGA1

• entrezGene:26088
• omim:606004
• swissprot:Q9UJY5

Proteins

Neuroscience

70384Da