GGA2
Domain
The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (DXXLL motif).
The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis.
The unstructured hinge region contains clathrin-binding but no autoinhibitory (DXXLL) motifs.
The GAE domain binds accessory proteins regulating GGAs function.
Function
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712).
Post-translational modifications
Ubiquitinated.
Sequence Similarities
Belongs to the GGA protein family.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Golgi apparatus
- trans-Golgi network membrane
- Peripheral membrane protein
- Endosome membrane
- Peripheral membrane protein
- Early endosome membrane
- Peripheral membrane protein
Alternative names
KIAA1080, GGA2, ADP-ribosylation factor-binding protein GGA2, Gamma-adaptin-related protein 2, VHS domain and ear domain of gamma-adaptin, Vear