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GGACT

Function

Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.

Sequence Similarities

Belongs to the gamma-glutamylcyclotransferase family.

Alternative names

A2LD1, GGACT, Gamma-glutamylaminecyclotransferase, AIG2-like domain-containing protein 1, Gamma-glutamylamine cyclotransferase

swissprot:Q9BVM4 entrezGene:87769 omim:613378