GGT5
Function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318). Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318). May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318). Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656).
Pathway
Sulfur metabolism; glutathione metabolism.
Lipid metabolism; leukotriene D4 biosynthesis.
Post-translational modifications
Cleaved by autocatalysis into a large and a small subunit.
Glycosylated.
Sequence Similarities
Belongs to the gamma-glutamyltransferase family.
Cellular localization
- Membrane
- Single-pass type II membrane protein
Alternative names
GGTLA1, GGT5, Glutathione hydrolase 5 proenzyme, Gamma-glutamyl transpeptidase-related enzyme, Gamma-glutamyltransferase 5, Gamma-glutamyltransferase-like activity 1, Gamma-glutamyltranspeptidase 5, Leukotriene-C4 hydrolase, GGT-rel, GGT 5