GGT7
Function
Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.
Pathway
Sulfur metabolism; glutathione metabolism.
Post-translational modifications
Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme.
Sequence Similarities
Belongs to the gamma-glutamyltransferase family.
Tissue Specificity
Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.
Cellular localization
- Membrane
- Single-pass type II membrane protein
Alternative names
GGTL3, GGTL5, GGT7, Glutathione hydrolase 7, Gamma-glutamyltransferase 7, Gamma-glutamyltransferase-like 3, Gamma-glutamyltransferase-like 5, Gamma-glutamyltranspeptidase 7, GGT 7