GID8
Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046).
Post-translational modifications
Polyubiquitinated through 'Lys-48'-polyubiquitin chains, leading to proteasomal degradation in the absence of Wnt stimulation.
Sequence Similarities
Belongs to the GID8 family.
Tissue Specificity
Up-regulated in colorectal cancer tissues (at protein level).
Cellular localization
- Cytoplasm
- Nucleus
- Localizes in the cytoplasm in the absence of Wnt stimulation and in the nucleus in the presence of Wnt stimulation.
Alternative names
C20orf11, TWA1, GID8, Glucose-induced degradation protein 8 homolog, Two hybrid-associated protein 1 with RanBPM, Twa1