Gja3
Function
Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Sequence Similarities
Belongs to the connexin family. Alpha-type (group II) subfamily.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cell junction
- Gap junction
Alternative names
Gap junction alpha-3 protein, Connexin-46, Cx46, Gja3