Gjc2
Developmental stage
Expression starts after birth in the central nervous system and parallels myelination process.
Function
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.
Sequence Similarities
Belongs to the connexin family. Gamma-type subfamily.
Tissue Specificity
Mainly expressed by oligodendrocytes in the central nervous system (at protein level).
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cell junction
- Gap junction
Alternative names
Gja12, Gjc2, Gap junction gamma-2 protein, Connexin-47, Gap junction alpha-12 protein, Cx47