gL
Function
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. The heterodimer gH/gL targets also host EPHA2 to promote viral entry.
Sequence Similarities
Belongs to the herpesviridae glycoprotein L family.
Cellular localization
- Virion membrane
- Peripheral membrane protein
- Extracellular side
- Host cell membrane
- Peripheral membrane protein
- Extracellular side
- Host Golgi apparatus
- Host trans-Golgi network
- gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.
Alternative names
BKRF2, gL, Envelope glycoprotein L