GLCE
Function
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.
Pathway
Glycan metabolism; heparan sulfate biosynthesis.
Glycan metabolism; heparin biosynthesis.
Sequence Similarities
Belongs to the D-glucuronyl C5-epimerase family.
Cellular localization
- Golgi apparatus membrane
- Single-pass type II membrane protein
Alternative names
KIAA0836, GLCE, D-glucuronyl C5-epimerase, Heparan sulfate C5-epimerase, Heparin/heparan sulfate:glucuronic acid C5-epimerase, Heparosan-N-sulfate-glucuronate 5-epimerase, Hsepi