GLG1
Developmental stage
Expressed both in adult and fetal tissues.
Function
Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
Post-translational modifications
Fucosylation is essential for binding to E-selectin.
N-glycosylated. Contains sialic acid residues.
Tissue Specificity
Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.
Cellular localization
- Golgi apparatus membrane
- Single-pass type I membrane protein
- Golgi outpost
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Golgi medial cisternae. Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation.
Alternative names
CFR1, ESL1, MG160, GLG1, Golgi apparatus protein 1, CFR-1, Cysteine-rich fibroblast growth factor receptor, E-selectin ligand 1, Golgi sialoglycoprotein MG-160, ESL-1