C1orf85

Expressed throughout embryogenesis (PubMed:11444019). After birth, there is a rapid increase in expression within the first week of life, reaching adult levels by week 2 (PubMed:27141234).

Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

Highly N-glycosylated (PubMed:19349973, PubMed:19489740). N-glycosylation is essential for GLMP stability and for MFSD1 lysosomal localization (PubMed:32959924).

Belongs to the GLMP family.

Detected in brain, heart, liver, kidney, lung, intestine, testis and spleen (PubMed:11444019, PubMed:19489740, PubMed:24487409). Expressed at highest levels in kidney cortex (PubMed:11444019, PubMed:19489740). However, another study reports highest expression levels in lung (PubMed:24487409). Expressed in myoblasts with expression increasing during differentiation into myotubes (PubMed:26707125).

• Lysosome membrane
• Single-pass type I membrane protein
• Lumenal side

Glycosylated lysosomal membrane protein, Lysosomal protein NCU-G1, Glmp

• entrezGene:56700
• swissprot:Q9JHJ3

Proteins

Metabolism

43804Da