GLP1R
Function
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449, PubMed:7517895, PubMed:8216285, PubMed:8405712). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449, PubMed:7517895, PubMed:8216285, PubMed:8405712). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
Post-translational modifications
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Glucagon-like peptide 1 receptor, GLP-1 receptor, GLP-1-R, GLP-1R, GLP1R