GLS2
Function
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
Sequence Similarities
Belongs to the glutaminase family.
Tissue Specificity
Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas.
Cellular localization
- Mitochondrion
Alternative names
GA, GLS2, GLS, L-glutaminase, L-glutamine amidohydrolase