Glutathione reductase, mitochondrial
Domain
Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface.
Function
Maintains high levels of reduced glutathione in the cytosol.
Sequence Similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Cellular localization
- Isoform Mitochondrial
- Mitochondrion
- Isoform Cytoplasmic
- Cytoplasm
Alternative names
Gr1, GR, GRase