Glutathione S-transferase A4
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).
Sequence Similarities
Belongs to the GST superfamily. Alpha family.
Tissue Specificity
Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver.
Cellular localization
- Cytoplasm
Alternative names
Glutathione S-transferase A4, GST class-alpha member 4, Glutathione S-transferase A4-4, GSTA4