Glutathione S-transferase Mu 4

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009).

Sequence Similarities

Belongs to the GST superfamily. Mu family.

Tissue Specificity

Expressed in a wide variety of tissues.

Cellular localization

• Cytoplasm

Alternative names

Glutathione S-transferase Mu 4, GST class-mu 4, GST-Mu2, GSTM4-4, Leukotriene C4 synthase GSTM4, GSTM4

Database links

swissprot:Q03013 omim:138333 genbank:NM_000850.3 entrezGene:2948