Glycine N-acyltransferase-like protein 2

Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine (PubMed:20305126, PubMed:22475485). Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine (PubMed:20305126).

Acetylation at Lys-19 drastically decreases the production of N-oleoyl and N-arachidonoyl glycines.

Belongs to the glycine N-acyltransferase family.

Expressed at highest levels in salivary gland and trachea. Also detected in thyroid gland, spinal cord, prostate, lung and fetal brain.

• Endoplasmic reticulum

Glycine N-acyltransferase-like protein 2, Acyl-CoA:glycine N-acyltransferase-like protein 2, GLYATL2

• entrezGene:219970
• omim:614762
• swissprot:Q8WU03

Proteins

Oncology

34277Da