Glycogenin-2
Function
Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
Pathway
Glycan biosynthesis; glycogen biosynthesis.
Post-translational modifications
Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-228.
Sequence Similarities
Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
Tissue Specificity
Detected in liver (at protein level) (PubMed:9857012). Expressed preferentially in liver, heart, and pancreas (PubMed:9346895).
Cellular localization
- Cytoplasm
- Nucleus
- Localizes to glycogen granules (glycosomes) in the cytoplasm (By similarity). Cytosolic localization is dependent on the actin cytoskeleton (By similarity).
Alternative names
Glycogenin-2, GN-2, GN2, GYG2