GMPR2
Function
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).
Sequence Similarities
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Tissue Specificity
Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.
Alternative names
GMP reductase 2, GMPR 2, Guanosine 5'-monophosphate oxidoreductase 2, Guanosine monophosphate reductase 2, GMPR2