GMPR2

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.

GMP reductase 2, GMPR 2, Guanosine 5'-monophosphate oxidoreductase 2, Guanosine monophosphate reductase 2, GMPR2

• entrezGene:51292
• omim:610781
• swissprot:Q9P2T1

Proteins

37874Da