GMPS
Function
Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
Involvement in disease
A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.
Pathway
Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
Cellular localization
- Cytoplasm
- Cytosol
Alternative names
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase, GMPS